上海中医药大学附属龙华医院脑病科专家叶青、袁晓蕾、张艳、袁灿兴对熟地平颤颗粒结合重复经颅磁刺激治疗帕金森氏病有了新的突破性研究

 

　　此次试验目的是观察熟地平颤颗粒结合重复经颅磁刺激对于改善帕金森病运动障碍及非运动症状方面有哪些决定性优势。

 

　　实验方法：将76名帕金森病患者随机分为治疗组(38例)在西药常规基础上给予熟地平颤颗粒联合高频重复经颅磁刺激治疗(rTMS)、对照组(38例)给予西药常规治疗，疗程共12周。

 

　　采用UPDRSII、III量表评分，自主神经症状量表(SCOPA-AUT)、帕金森病睡眠量表(PDSS)、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)、简易智能精神状态量表(MMSE)、帕金森病睡眠量表(PDSS)、帕金森病生存质量问卷(PDQ-39)评价临床疗效。

 

　　结果：(1)在运动障碍评分及运动并发症方面：对照组、治疗组各阶段UPDRSII评分与治疗前比较无明显差异。治疗组在治疗后的第8周与第12周UPDRSⅢ评分明显低于同期对照组(P<0.01)。(2)在非运动症状方面：对照组、治疗组各阶段MMSE评分无明显差异，同期两组间比较无明显差异；治疗组至第12周HAMA、HAMD、SCOPA-AUT、PDQ39评分均明显低于对照组，PDSS评分高于对照组(P<0.05)。两组均未见明显不良反应。

 

结论：熟地平颤颗粒结合高频rTMS对帕金森病运动障碍及非运动症状均有效果且安全性佳。

 

　　Objective:ToobservetheadvantagesofShudiPingchangranulecombinedwithrepetitivetran-scranialmagneticstimulationinimprovingmotordysfunctionandnon-motorsymptomsofPar-kinson’sdisease.Method:76casesofParkinsondiseasewererandomlydividedintocontrolgroup(38cases)receivedtheroutinetreatmentofWesternmedicineandtreatmentgroup(38cases)receivedShudiPingchangranulecombinedwithhighfrequencyrepetitivetranscranialmagneticstimulation(rTMS)onthebasisofcontrolgroup;thetreatmentlastedfor12weeks,usingUPDRSIIandIIIscore,autonomicsymptomsscale(SCOPA-AUT),Parkinson’sdiseaseSleepScale(PDSS),HamiltonAnxietyScale(HAMA),HamiltonDepressionScale(HAMD),MiniMentalStateScale(MMSE),Parkinson’sdiseaseSleepScale(PDSS),thequalityofthesurvivalquestionnairetoevaluateParkinson’sdisease(PDQ-39)clinicalefficacy.Result:(1)TherewerenosignificantdifferencesinUPDRSscoresbetweenthecontrolgroupandthetreatmentgroupbeforeandaftertreatment.TheUPDRSscoreofthetreatmentgroupwassignificantlylowerthanthatofthecontrolgroup(P<0.01)ateighthandtwelfthweeksaftertreatment.(2)Scoresinnon-motorsymptoms:thereisnosignificantdifferencebeforeandaftertreatmentbetweenthetreatmentgroupandcontrolgroupineachstageoftheMMSEscore,comparednosignificantdifferencebetweenthetwogroups;forthetreatmentgroupto12thweeks,HAMA,HAMD,SCOPA-AUT,PDQ39scoresweresignificantlylowerthanthecontrolgroup,PDSSscorehigherthanthecontrolgroup(P<0.05).Therewerenoobviousadversereactionsinthetwogroups.Conclusion:ShudiPingchangranulecombinedwithrTMShadgoodeffectsandsecuritiesforimprovingdyskinesiaandnon-motorsymptomsofParkinson’sdisease.

 

　　文章引用:

 

　　叶青,袁晓蕾,张艳,袁灿兴(2017)熟地平颤颗粒结合重复经颅磁刺激治疗帕金森氏病的临床研究。中医学，6，60-67.doi:10.12677/TCM.2017.62011

 

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